Preparation method of 3-(4-bromophenyl)piperidin-2-one_Kain Industrial Additive

Background and overview[1] 3-(4-Bromophenyl)piperidin-2-one can be used as a pharmaceutical synthesis intermediate. Preparation[1] 3-(4-Bromophenyl)piperidin-2-one is prepared as follows: To ethyl 2-(4-bromophenyl)-5-((tert-butoxycarbonyl)amino)valerate ethyl ester (45.0g, 0.11mol) of 2M ethanol solution of hydrochloric acid (200mL) was added dropwise to 200mL of ethanol. After the dropwise addition was completed, the reaction was stirred for 30 minutes. LC-MS showed that the raw material disappeared. Concentrate to obtain the residue mixed…