Application of 2-bromo-4-fluorophenyl acetonitrile_Kain Industrial Additive

Background and Overview 2-Bromo-4-fluorophenyl acetonitrile is a phenylacetonitrile compound that can be used as a pharmaceutical intermediate. Preparation[1] Heat a solution of NaCN (2.0 equiv) in DMSO (6 mL) to 90 °C. The oil bath was removed and 2-bromo-4-fluorobenzyl bromide (1.0 equiv, 6.09 mmol) was slowly added. After the mixture reached 50 °C, water (120 mL) was added. The mixture was extracted with CH2Cl2 (3 ×…