Application of 1-(2,4-dichlorophenyl)piperazine dihydrochloride_Kain Industrial Additive
Background and overview[1] 1-(2,4-Dichlorophenyl)piperazine dihydrochloride can be used as a pharmaceutical synthesis intermediate. Its free base can be prepared by Buchward reaction from piperazine and 2,4-dichlorobromobenzene. Preparation[1] The free base of 1-(2,4-dichlorophenyl)piperazine dihydrochloride is prepared as follows: Mix and dissolve BINAP (219mg), palladium(II) acetate (397mg, 0.176mmol), tBuONa (1.19g, 12.3mmol), piperazine (837mg, 9.73mmol) in THF (40mL) and keep at room temperature Stir under nitrogen atmosphere for 30…
