Preparation method of (1S,3AR,6AS)-octahydrcyclopenta[C]pyrrole-1-carboxylic acid tert-butyl ester oxalate_Kain Industrial Additive
Background and overview[1] (1S,3AR,6AS)-Otahydrocyclopenta[C]pyrrole-1-carboxylic acid tert-butyl ester oxalate is an S-configured nitrogen heterocycle and an intermediate of telaprevir. S-configuration nitrogen heterocycles are widely concerned as common compounds in stereochemistry and important intermediates for various drugs. (1S,3AR,6AS)-Otahydrocyclopenta[C]pyrrole-1-carboxylic acid tert-butyl ester oxalate can be made from cis-7-azabicyclo[3.3.0]octane hydrochloride. It is prepared through a five-step reaction. Preparation[1] Step 1: Dissolve 131kg of K2CO3 into 125kg of water, add 25kg…
(3aR, 4S, 5R, 6aS)-(-)-hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[b]furan-5-yl 1,1′-biphenyl Preparation method of -4-formate ester_Kain Industrial Additive
Background and overview[1] Prostaglandins are an important class of endogenous physiologically active substances. They are important mediators in various physiological processes and have high pharmacological activity. Clinically, prostaglandins are all artificially synthesized. Coreylactonephenylbenzoate, (3aR, 4S, 5R, 6aS)-(-)-hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[ b] Furan-5-yl 1,1′-biphenyl-4-carboxylate) is a chiral intermediate for the synthesis of PGF2α prostaglandin drugs. Its molecular formula is C21H20O5 and its chemical name is hexahydro-4-(hydroxymethyl). -2-Oxo-2H-cyclopenta[b]furan-5-yl 1,1′-biphenyl-4-carboxylate, usually including…